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A message has been sent to your recipient's email address with a link to the content webpage. Your name: is required Error: This is required. Your email: is required Error: This is required Error: Not a valid value. Send to: is required Error: This is required Error: Not a valid value. Over 65? Pregnant or planning a pregnancy? Consumer medicine information CMI Reporting side effects Data sources Disclaimer What it is used for Short-term treatment of symptoms resulting from the natural or surgical menopause in post menopausal women.
How to take it The way to take this medicine is: Oral. Evidence implies that tibolone is able to increase arousal and libido in postmenopausal women to a greater extent than estrogen therapy alone.
Data on the effects of tibolone on cognitive function are not sufficient to establish if estrogen-based therapies are more effective than tibolone in improving cognitive processes in postmenopausal women. Further long-term and specifically designed studies are needed on such effects. In conclusion, the pharmacological profile and the clinical effects of tibolone make this synthetic steroid an additional option for clinicians in selecting the most appropriate treatment to counteract individually the physical and psychological symptoms of each postmenopausal woman.
National Center for Biotechnology Information , U. Journal List Neuropsychiatr Dis Treat v. Neuropsychiatr Dis Treat. Author information Copyright and License information Disclaimer. All rights reserved. This article has been cited by other articles in PMC. Abstract Tibolone is a synthetic molecule used extensively for the management of menopausal symptoms, with the proposed additional advantage of enhanced mood and libido.
Keywords: tibolone, menopause, mood, well-being and sexuality. Introduction The climateric period and the postmenopause are characterized by several endocrine, neuroendocrine, and metabolic modifications that produce a variety of short-term and long-term symptoms. Tibolone, mood, and well-being Menopause-associated symptoms impair QoL for many women. Open in a separate window. Figure 1. Figure 2. Tibolone and cognition The term cognition encompasses the spectrum of intellectual abilities, including attention, learning and memory, language, perception, abstract reasoning, and judgment.
Figure 3. Conclusion Data originating from basic science and from clinical trials highlight that tibolone exerts encouraging effects on climacteric symptoms. Figure 4.
Central effects of tibolone administration. Tibolone: a review. The effect of tibolone versus continuous combined norethisterone acetate and oestradiol on memory, libido and mood of postmenopausal women: a pilot study. Elevated levels of plasma beta-endorphin in a group of women with polycystic ovarian disease. Fertil Steril. Menopausal syndrome: plasma levels of — endorphin in postmenopausal women using a specific radioim-munoassay.
Neurosteroids: a new function in the brain. Biol Cell. Neurosteroids: of the nervous system, by the nervous system, for the nervous system. Recent Prog Horm Res.
Neurosteroids: beginning of the story. Int Rev Neurobiol. Failure of tibolone to potentiate the pharmacological effect of fluoxetine in postmenopausal major depression. J Womens Health Larchmt ; 12 —9. Comparative effects of estrogens plus androgens and tibolone on bone, lipid pattern and sexuality in postmenopausal women.
Treatment of climacteric complaints with Org OD a comparative study with oestradiol valerate and placebo. Androgen replacement therapy: a commentary. J Clin Endocrinol Metab. The effects of tibolone on mood and libido. When to suspect androgen deficiency other than at menopause. Androgen and postmenopausal women. Testosterone influences libido and well-being in women. Trends Endocrinol Metab. Receptor profiling and endocrine interactions of tibolone. Tibolone: a compound with tissue specific inhibitory effects on sulfatase.
Mol Cell Endocrinol. Differential effects on the androgen status of postmenopausal women treated with tibolone and continuous combined estradiol and norethindrone acetate replacement therapy. Cognitive effects of 10 years of hormone-replacement therapy with tibolone. J Clin Psychopharmacol. Beta-endorphin in the male rat pituitarytestosterone influences the effects of cocaine.
Brain Res Bull. HRT In Climacteric and aging brain. It is possible that there may be some ascertainment bias, in that women with an increased risk of breast cancer were prescribed tibolone in preference to conventional MHT. It is also possible that the reassuring oestrogen metabolism data for tibolone has overlooked the contribution of progestogen to breast cancer risk, as was identified in the WHI study.
Note: Medical and scientific information provided and endorsed by the Australasian Menopause Society might not be relevant to a particular person's circumstances and should always be discussed with that person's own healthcare provider. This Information Sheet may contain copyright or otherwise protected material.
Reproduction of this Information Sheet by Australasian Menopause Society Members and other health professionals for clinical practice is permissible. Any other use of this information hardcopy and electronic versions must be agreed to and approved by the Australasian Menopause Society.
Members Members Login Membership Application. Membership Renewal Members Help. Maori: Menopause what are the symptoms? Vietnamese: Menopause what are the symptoms? Resources Fact Sheets Menopause what are the symptoms? Complementary medicine options for menopausal symptoms Will menopause affect my sex life? Self Assessment Tools Are you at risk of breast cancer? Are you at risk of cardiovascular disease?
Are you at risk of osteoporotic fracture? Key Points Tibolone acts as a combined oral hormone therapy for treating menopausal symptoms It has not been researched as extensively as some other forms of HT Evidence for improved sexual function with tibolone is not strong An increased risk of stroke was found in women over 60 years of age It is contraindicated in women who have had breast cancer Risks vs benefits for an individual need to take into account their co-morbidities.
How effective is tibolone? Who can use tibolone? Side-effects of tibolone Side-effects may include headache, dizziness, nausea, abdominal pain, swollen feet and itching.
Safety of tibolone In the LIFT study of tibolone for the prevention of bone loss and osteoporotic fractures, there was an increase in stroke in the tibolone group compared with the placebo group 4. This was mainly seen in women over 60 years of age.
The increase among women in their 50s was 4 extra cases per and among women in their 60s, an extra 13 cases per women. Tibolone decreases total and LDL cholesterol and triglyceride levels.
However, it also decreases HDL cholesterol. Pain in the lower abdomen, increased weight, unusual hair growth, breast tenderness If any of these become troublesome, speak with your doctor Vaginal thrush redness and itching in the vagina Speak with your doctor or pharmacist for advice Vaginal bleeding and spotting This may happen when you first start tibolone and is nothing to worry about. If it continues for more than a few months, you should let your doctor know about it. If you have any questions about this medicine ask your pharmacist.
Are you protected against flu? Further reading and references. Join the discussion on the forums. Health Tools Feeling unwell? Assess your symptoms online with our free symptom checker. Start symptom checker. Common tibolone side-effects these affect fewer than 1 in 10 women. This may happen when you first start tibolone and is nothing to worry about.
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