Why does tamoxifen cause weight gain




















Your metabolism the rate at which you burn calories slows as you age. So naturally, losing weight becomes much more difficult than it once was. Luckily, there are ways, like exercise, that can help you battle a slowing metabolism. Studies show that physical activity will decline after a breast cancer diagnosis, which is completely natural. You are recovering from surgery or chemotherapy.

However, less activity means fewer calories burned, which can easily translate into increased weight. Make no mistake, losing weight is a challenge even under normal circumstances. And it can be even harder after breast cancer.

When you hear you will gain weight after a diagnosis and not many women will ever lose weight enough times, that belief starts to solidify. So we have got to expect a different result. And if you feel hopeless, what action will you most likely take? So now I ask, How can you challenge this belief? How can you trigger a new emotion? Not only for my family but for myself and for others.

I will be an inspiration for other women in my situation. And when you are determined, like I know you are and like Kathy is, you will take action.

And actions lead to results. Weight loss after a diagnosis can be a long road with many bumps and discouragements along the way. This weight gain may be because of the enzyme lipoprotein lipase LPL , which is controlled by insulin.

LPL sits on the surface of cells and pulls fat out of the bloodstream and into the cell. If LPL is on a fat cell, it pulls fat into the cell and makes it fatter. This could be one reason why some women gain weight after menopause or after breast cancer treatment that dramatically decreases estrogen levels.

With less estrogen in the body, LPL can pull fat into fat cells and store it there. The shock of a diagnosis, the disruption of your life, getting through and beyond surgery and radiation, the strain of relationships at home and at work, financial stress, and less physical activity all may contribute to weight gain. During chemo, extra fluids and steroids together with less physical activity and a yearning for sweets all combine to cause weight gain.

And like many people, you may be certain that taking a hormonal therapy medication makes you gain weight and makes it nearly impossible to lose weight. But two of the major studies conducted in the United States and Canada by the National Surgical Adjuvant Breast and Bowel Project NSABP, a cooperative research group showed that women taking a placebo a sugar pill were just as likely to gain weight as women taking tamoxifen.

Because aromatase inhibitors are relatively new, research on aromatase inhibitors and weight gain hasn't been done yet. Losing weight becomes much harder as we grow older, but it can still be done with careful diet changes and exercise.

Be nice to yourself; don't punish yourself. There are lots of good reasons to maintain a healthy weight. Prognostic indicators, changes in weight, and disease status from diagnosis to the end of treatment were studied in consecutive Stage I and II breast cancer patients, not receiving systemic chemotherapy, admitted from to the present, with observation periods ranging from years.

A mean weight gain of 1. Weight gain during treatment with tamoxifen was not correlated with treatment duration or with recurrence or survival.



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